Clinico-Histopathological Spectrum of Infectious Granulomatous Dermatoses in Western India- A Representative Study from Mumbai
Clinico-Histopathological Spectrum of Infectious Granulomatous Dermatoses in Western India- A Representative Study from Mumbai
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Introduction: Infectious Granulomatous Dermatoses (IGDS) have various aetiological factors with a considerable overlap in the histopathological and clinical features, thus posing a diagnostic dilemma for Demi Tasse Spoons dermatologists and pathologists.Aim: We aimed at determining the histopathological profile of IGDS correlating it with clinical features with an attempt to find the aetiology.Materials and Methods: In a cross-sectional study conducted in a tertiary referral center of Mumbai over two years, out of 1872 skin biopsies received, 239 histopathologically diagnosed cases of IGDS were studied for histopathological features of granuloma.
A clinico-histopathological correlation was attempted.Chi-square test was used for comparison of proportions of different groups.Results: Leprosy (211 cases) and tuberculosis (28 cases) were the commonest histopathologically diagnosed IGDS.
Leprosy spectrum included BT (30.33% cases), followed by TT (21.32%), BL and LL and 21.
79% cases of lepra reactions.Skin TB biopsies on histopathology showed lupus vulgaris (53.85% cases), scrofuloderma (15.
38%), TBVC and papulonecrotic tuberculid (11.54% each).In leprosy maximum clinico-pathological agreement was seen at tuberculoid pole (TT 72.
7% and BT 56.6%).Among tuberculosis cases, scrofuloderma (100%) and lupus vulgaris (53.
8%) showed maximum agreement.Conclusion: Leprosy and skin TB are the commonest IGDS in Mumbai region though difficult to diagnose and subcategorize with certainty during initial stages.Histopathology plays the important #9 VERY LIGHT BLOND role to elucidate the dilemma.
This being a single center study, more such studies with a larger sample size are recommended to get more elaborate data and regional prevalence of these IGDS for a better overall approach to prevention, treatment and control.